Bioinformatics analysis identifies GLUD1 as a prognostic indicator for clear cell renal cell carcinoma.

ABSTRACT:

Background

Renal cell carcinoma (RCC) is a common primary tumor of the kidney and is divided into three major subtypes, of which clear cell renal cell carcinoma (ccRCC) has the highest incidence. Glutamate dehydrogenase 1 (GLUD1) encodes glutamate dehydrogenase 1, which catalyzes the oxidative deamination of glutamate.

Methods

We analyzed TCGA data using R language software and used multiple online databases to explore the relationship of GLUD1 with signaling pathways and drug sensitivity as well as GLUD1 protein expression and methylation.

Results

The results showed that GLUD1 mRNA expression was reduced in tumor tissues and correlated with the progression of ccRCC. Univariate and multivariate Cox analysis showed that GLUD1 could be used as a prognostic marker for cc

SUBMITTER: Liu S 

PROVIDER: S-EPMC10799526 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature