Influence of perinatal and childhood exposure to tobacco and mercury in children's gut microbiota.

ABSTRACT:

Background

Early life determinants of the development of gut microbiome composition in infants have been widely investigated; however, if early life pollutant exposures, such as tobacco or mercury, have a persistent influence on the gut microbial community, its stabilization at later childhood remains largely unknown.

Objective

In this exposome-wide study, we aimed at identifying the contribution of exposure to tobacco and mercury from the prenatal period to childhood, to individual differences in the fecal microbiome composition of 7-year-old children, considering co-exposure to a width of established lifestyle and clinical determinants.

Methods

Gut microbiome was studied by 16S rRNA amplicon sequencing in 151 children at the genus level. Exposure to tobacco was quan

SUBMITTER: Perez-Castro S 

PROVIDER: S-EPMC10799562 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature