Longitudinal genetically detectable minimal residual disease by fluorescence in situ hybridization confers a poor prognosis in myeloma.

ABSTRACT:

Background

Deeper depth of response (DpR) after induction therapy, especially gain of negative minimal residual disease (MRD), has been linked to prolonged survival in multiple myeloma (MM). However, flow-MRD examination focuses on the numbers but not on the biological characteristics of residual plasma cells (PCs).

Objectives

To explore whether the genetic features of residual tumor cells affect the survival time of patients with MM.

Design

A retrospective cohort study.

Methods

We investigated the clonality of cytogenetic abnormalities (CAs) of the residual PCs using interphase fluorescence in situ hybridization (iFISH) in the National Longitudinal Cohort of Hematological Diseases in China (NCT04645199). Here, a longitudinal cohort of 269 patients with

SUBMITTER: Cui J 

PROVIDER: S-EPMC10799601 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature