Prognostic significance of integrating total metabolic tumor volume and EGFR mutation status in patients with lung adenocarcinoma.

ABSTRACT:

Background

The objective of this study was to investigate the prognostic significance of total metabolic tumor volume (TMTV) derived from baseline ¹⁸F-2-fluoro-2-deoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT), in conjunction with epidermal growth factor receptor (EGFR) mutation status, among patients with lung adenocarcinoma (LUAD).

Methods

We performed a retrospective analysis on 141 patients with LUAD (74 males, 67 females, median age 67 (range 34-86)) who underwent ¹⁸F-FDG PET/CT and had their EGFR mutation status determined. Optimal cutoff points for TMTV were determined using time-dependent receiver operating characteristic curve analysis. The survival difference was compared using Cox regression analysi

SUBMITTER: Jiang M 

PROVIDER: S-EPMC10799611 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature