A decision analysis comparing 3 active surveillance protocols for the treatment of patients with low-risk prostate cancer.

ABSTRACT:

Background

Active surveillance (AS) is a viable management option for approximately 50% of men who are newly diagnosed with prostate cancer. To the authors' knowledge, no direct comparisons between the different variants of AS protocols have been conducted to date. The authors developed a microsimulation decision model to evaluate which of 3 alternative AS protocols is optimal for men with low-risk prostate cancer, and compared each of these with immediate treatment.

Methods

Men who were diagnosed with low-risk prostate cancer at age 65 years were modeled as having been treated with either immediate therapy or via each of 3 AS protocols. Modeled AS protocols represent those in the literature; a modified AS protocol was included in a sensitivity analysis. Immediate therapy in

SUBMITTER: White C 

PROVIDER: S-EPMC10799655 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature