Ontology highlight
ABSTRACT:
SUBMITTER: Bok S
PROVIDER: S-EPMC10799660 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Bok Seoyeon S Yallowitz Alisha R AR Sun Jun J McCormick Jason J Cung Michelle M Hu Lingling L Lalani Sarfaraz S Li Zan Z Sosa Branden R BR Baumgartner Tomas T Byrne Paul P Zhang Tuo T Morse Kyle W KW Mohamed Fatma F FF Ge Chunxi C Franceschi Renny T RT Cowling Randy T RT Greenberg Barry H BH Pisapia David J DJ Imahiyerobo Thomas A TA Lakhani Shenela S Ross M Elizabeth ME Hoffman Caitlin E CE Debnath Shawon S Greenblatt Matthew B MB
Nature 20230920 7980
Craniosynostosis is a group of disorders of premature calvarial suture fusion. The identity of the calvarial stem cells (CSCs) that produce fusion-driving osteoblasts in craniosynostosis remains poorly understood. Here we show that both physiologic calvarial mineralization and pathologic calvarial fusion in craniosynostosis reflect the interaction of two separate stem cell lineages; a previously identified cathepsin K (CTSK) lineage CSC<sup>1</sup> (CTSK<sup>+</sup> CSC) and a separate discoidin ...[more]