Increased development of T-bet⁺CD11c⁺ B cells predisposes to lupus in females: Analysis in BXD2 mouse and genetic crosses.

ABSTRACT: Cardinal features of lupus include elevated B cell activation and autoantibody production with a female sex preponderance. We quantified interactions of sex and genetic variation on the development of autoimmune B-cell phenotypes and autoantibodies in the BXD2 murine model of lupus using a cohort of backcrossed progeny (BXD2 x C57BL/6J) x BXD2. Sex was the key factor leading to increased total IgG, IgG2b, and autoantibodies. The percentage of T-bet⁺CD11c⁺ IgD⁺ activated naive B cells (aNAV) was higher in females and was associated with increased T-bet⁺CD11c⁺ IgD^- age-related B cells, Fas⁺GL7⁺ germinal center B cells, Cxcr5^-Icos⁺ peripheral T-helper cells, and Cxcr5⁺Icos<

SUBMITTER: Sullivan KA 

PROVIDER: S-EPMC10799694 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature