Sex-Specific Genetic Risks for Adverse Outcomes After Coronary Revascularization Procedures.

ABSTRACT: Men and women have differing risks of adverse events after revascularization procedures and these differences could be partially driven by genetics. We studied the sex-specific differences in associations of polygenic risk scores (PRSs) with atrial fibrillation (AF), ischaemic stroke (STR), intracranial Haemorrhage (ICH), myocardial infarction (MI), and gastrointestinal Haemorrhage (GIH) in coronary revascularization patients. The study cohort comprised 5,561 and 17,578 revascularized women and men. All participants underwent genotyping and register-based follow-up from 1961-2021. We calculated PRSs for all individuals and used Cox models with interaction term to examine the sex-specific associations between the PRSs and adverse outcomes after revascularization. The AF-PRS was more strongl

SUBMITTER: Nurkkala JM 

PROVIDER: S-EPMC10799751 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature