Acute and long-term toxicity in primary hypofractionated external photon radiation therapy in patients with localized prostate cancer.

ABSTRACT:

Background

Compelling evidence exists for the iso-effectiveness and safety of moderate hypofractionated radiotherapy (Hypo-RT) schedules [1, 2]. However, international guidelines are not congruent regarding recommendation of ultrahypofractionated radiotherapy (UHF-RT) to all risk groups.

Methods

The current review gives an overview of clinically relevant toxicity extracted from major randomized controlled trials (RCT) trials comparing conventional to hypofractionated regimes in the primary setting of external photon radiation. Functional impairments are reported by using physician-rated and patient-reported scores using validated questionnaires.

Results

The uncertain radiobiology of the urethra/bladder when applying extreme hypofractionation may have contributed to wo

SUBMITTER: Lilleby W 

PROVIDER: S-EPMC10799812 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature