Early life stress and body-mass-index modulate brain connectivity in alcohol use disorder.

ABSTRACT: Early life stress (ELS) significantly increases susceptibility to alcohol use disorder (AUD) by affecting the interplay between the executive and the salience networks (SNs). The link between AUD and higher body-mass index (BMI) is known, but we lack understanding of how BMI impacts the relationship between ELS and brain connectivity in individuals with AUD. To bridge this gap, we investigated the main and interaction effects of ELS and BMI on brain connectivity in individuals with AUD compared to non-AUD participants (n = 77 sex-matched individuals per group). All participants underwent resting-state functional magnetic resonance imaging, revealing intriguing positive functional connectivity between SN seeds and brain regions involved in somatosensory processing, motor coordination and ex

SUBMITTER: Agarwal K 

PROVIDER: S-EPMC10799859 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature