Interindividual- and blood-correlated sweat phenylalanine multimodal analytical biochips for tracking exercise metabolism.

ABSTRACT: In situ monitoring of endogenous amino acid loss through sweat can provide physiological insights into health and metabolism. However, existing amino acid biosensors are unable to quantitatively assess metabolic status during exercise and are rarely used to establish blood-sweat correlations because they only detect a single concentration indicator and disregard sweat rate. Here, we present a wearable multimodal biochip integrated with advanced electrochemical electrodes and multipurpose microfluidic channels that enables simultaneous quantification of multiple sweat indicators, including phenylalanine and chloride, as well as sweat rate. This combined measurement approach reveals a negative correlation between sweat phenylalanine levels and sweat rates among individuals, which further ena

SUBMITTER: Zhong B 

PROVIDER: S-EPMC10799919 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature