Genetic evidence for the causal relations between metabolic syndrome and psychiatric disorders: a Mendelian randomization study.

ABSTRACT: Emerging evidence reveals associations between metabolic syndrome (MetS) and psychiatric disorders (PDs), although causality remains uncertain. Consequently, we conducted Mendelian randomization (MR) to systematically evaluate the causality between MetS and PDs. Linkage disequilibrium score regression estimated the heritability of PDs and their genetic correlations with MetS. In primary analyses, the main model employed inverse variance weighting method, with sensitivity analyses using various MR models to ensure robustness. Replication MR analyses, involving cohorts distinct from those in the primary analyses, were performed to validate the generalizability of the findings. Multivariable MR analyses were carried out to account for genetically predicted body mass index (BMI). As a result,

SUBMITTER: Gao X 

PROVIDER: S-EPMC10799927 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature