Radiation cataract in Heterogeneous Stock mice after γ-ray or HZE ion exposure.

ABSTRACT: Health effects of space radiation are a serious concern for astronauts on long-duration missions. The lens of the eye is one of the most radiosensitive tissues in the body and, therefore, ocular health risks for astronauts is a significant concern. Studies in humans and animals indicate that ionizing radiation exposure to the eye produces characteristic lens changes, termed "radiation cataract," that can affect visual function. Animal models of radiation cataractogenesis have previously utilized inbred mouse or rat strains. These studies were essential for determining morphological changes and dose-response relationships between radiation exposure and cataract. However, the relevance of these studies to human radiosensitivity is limited by the narrow phenotypic range of genetically homogen

SUBMITTER: Kleiman NJ 

PROVIDER: S-EPMC10800003 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature