Causal relationship between multiple sclerosis and cortical structure: a Mendelian randomization study.

ABSTRACT:

Background

Observational studies have suggested an association between multiple sclerosis (MS) and cortical structure, but the results have been inconsistent.

Objective

We used two-sample Mendelian randomization (MR) to assess the causal relationship between MS and cortical structure.

Methods

MS data as the exposure trait, including 14,498 cases and 24,091 controls, were obtained from the International Multiple Sclerosis Genetics Consortium. Genome-wide association study (GWAS) data for cortical surface area (SAw/nw) and thickness (THw/nw) in 51,665 individuals of European ancestry were obtained from the ENIGMA Consortium. The inverse-variance weighted (IVW) method was used as the primary analysis for MR. Sensitivity analyses were conducted to evaluate heterogeneity a

SUBMITTER: Sun D 

PROVIDER: S-EPMC10800041 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature