Plasma metabolite profile of legume consumption and future risk of type 2 diabetes and cardiovascular disease.

ABSTRACT:

Background

Legume consumption has been linked to a reduced risk of type 2 diabetes (T2D) and cardiovascular disease (CVD), while the potential association between plasma metabolites associated with legume consumption and the risk of cardiometabolic diseases has never been explored. Therefore, we aimed to identify a metabolite signature of legume consumption, and subsequently investigate its potential association with the incidence of T2D and CVD.

Methods

The current cross-sectional and longitudinal analysis was conducted in 1833 PREDIMED study participants (mean age 67 years, 57.6% women) with available baseline metabolomic data. A subset of these participants with 1-year follow-up metabolomics data (n = 1522) was used for internal validation. Plasma metabolites were assesse

SUBMITTER: Margara-Escudero HJ 

PROVIDER: S-EPMC10800064 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature