Rasal1 regulates calcium dependent neuronal maturation by modifying microtubule dynamics.

ABSTRACT:

Background

Rasal1 is a Ras GTPase-activating protein which contains C2 domains necessary for dynamic membrane association following intracellular calcium elevation. Membrane-bound Rasal1 inactivates Ras signaling through its RasGAP activity, and through such mechanisms has been implicated in regulating various cellular functions in the context of tumors. Although highly expressed in the brain, the contribution of Rasal1 to neuronal development and function has yet to be explored.

Results

We examined the contributions of Rasal1 to neuronal development in primary culture of hippocampal neurons through modulation of Rasal1 expression using molecular tools. Fixed and live cell imaging demonstrate diffuse expression of Rasal1 throughout the cell soma, dendrites and axon which loc

SUBMITTER: Deurloo MHS 

PROVIDER: S-EPMC10800070 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature