MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning.

ABSTRACT:

Background

The enrichment of peri-cancerous adipose tissue is a distinctive feature of colorectal cancer (CRC), accelerating disease progression and worsening prognosis. The communication between tumor cells and adjacent adipocytes plays a crucial role in CRC advancement. However, the precise regulatory mechanisms are largely unknown. This study aims to explore the mechanism of migration and invasion inhibitory protein (MIIP) downregulation in the remodeling of tumor cell-adipocyte communication and its role in promoting CRC.

Results

MIIP expression was found to be decreased in CRC tissues and closely associated with adjacent adipocyte browning. In an in vitro co-culture model, adipocytes treated with MIIP-downregulated tumor supernatant exhibited aggravated browning and lip

SUBMITTER: Wang Q 

PROVIDER: S-EPMC10800076 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature