The Incidence of Multiple Fusions in a Series of Pediatric Soft Tissue and Bone Tumors.

ABSTRACT:

Background

Next generation sequencing (NGS) has increased the detection of fusion genes in cancer. NGS has found multiple fusions in single tumor samples; however, the incidence of this in pediatric soft tissue and bone tumors (PSTBTs) is not well documented. The aim of this study is to catalogue the incidence of multiple fusions in a series of PSTBTs, and apply a modified gene fusion classification system to determine clinical relevance.

Methodology

RNA from 78 bone and soft tissue tumors and 7 external quality assessment samples were sequenced and analyzed using recently-described Metafusion (MF) software and classified using a modification of previously-published schema for fusion classification into 3 tiers: 1, strong clinical significance; 2, potential clinical signific

SUBMITTER: MacKeracher A 

PROVIDER: S-EPMC10800079 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature