Integrin-associated transcriptional characteristics of circulating tumor cells in breast cancer patients.

ABSTRACT:

Background

Integrins enable cell communication with the basal membrane and extracellular matrix, activating signaling pathways and facilitating intracellular changes. Integrins in circulating tumor cells (CTCs) play a significant role in apoptosis evasion and anchor-independent survival. However, the link between CTCs expressing different integrin subunits, their transcriptional profile and, therefore, their functional activity with respect to metastatic potential remains unclear.

Methods

Single-cell RNA sequencing of CD45-negative cell fraction of breast cancer patients was performed. All CTCs were divided into nine groups according to their integrin profile.

Results

СTCs without the gene expression of integrins or with the expression of non-complementary α and β sub

SUBMITTER: Grigoryeva E 

PROVIDER: S-EPMC10800097 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature