Pharmacodynamic effects of molidustat on erythropoiesis in healthy cats.

ABSTRACT:

Background

Inhibition of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) stimulates erythropoiesis in rats, dogs, monkeys, and humans.

Hypothesis/objective

Determine if molidustat, a novel HIF-PH inhibitor, stimulates erythropoiesis in healthy cats.

Animals

Seventeen healthy adult laboratory cats.

Methods

Randomized, placebo-controlled study. Cats were treated PO once daily with suspensions of 0 (Group 1; n = 6), 5 (Group 2; n = 6), or 10 (Group 3; n = 5) mg/kg of molidustat. Effects on red blood cell parameters, reticulocyte indices and plasma erythropoietin (EPO) concentrations were evaluated. Molidustat treatment was stopped when hematocrit (HCT) exceeded 60%.

Results

Compared to placebo, a significant increase in mean HCT was evident starting on

SUBMITTER: Boegel A 

PROVIDER: S-EPMC10800175 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature