Renal amyloid-A amyloidosis in cats: Characterization of proteinuria and biomarker discovery, and associations with kidney histology.

ABSTRACT:

Background

Amyloid A (AA) amyloidosis is a protein misfolding disease arising from serum amyloid A (SAA). Systemic AA amyloidosis recently was shown to have a high prevalence in shelter cats in Italy and was associated with azotemia and proteinuria.

Objectives

Investigate urine protein profiles and diagnostic biomarkers in cats with renal AA amyloidosis.

Animals

Twenty-nine shelter cats.

Methods

Case-control study. Cats with renal proteinuria that died or were euthanized between 2018 and 2021 with available necropsy kidney, liver and spleen samples, and with surplus urine collected within 30 days before death, were included. Histology was used to characterize renal damage and amyloid amount and distribution; immunohistochemistry was used to confirm AA amyloidos

SUBMITTER: Palizzotto C 

PROVIDER: S-EPMC10800178 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature