Tolerability of long-term cannabidiol supplementation to healthy adult dogs.

ABSTRACT:

Background

Cannabidiol (CBD) has therapeutic potential in companion animals. Shorter-term studies have determined that CBD is well tolerated in dogs with mild adverse effects and an increase in alkaline phosphatase (ALP) activity. There is need to assess CBD's long-term tolerability.

Hypothesis

Determine the long-term tolerability of CBD administered PO to healthy dogs for 36 weeks at dosages of 5 and 10 mg/kg body weight (BW)/day. Our hypothesis was that CBD would be well tolerated by dogs.

Methods

Eighteen healthy adult beagle dogs were randomly assigned to 3 groups of 6 each that received 0, 5, or 10 mg/kg BW/day CBD PO. Dogs were adapted to their housing for 3 weeks and received treatment for 36 weeks once daily with food. Adverse events (AEs) were recorded daily.

SUBMITTER: Corsato Alvarenga I 

PROVIDER: S-EPMC10800185 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature