Association of the FGF4L2 retrogene with fibrocartilaginous embolic myelopathy in dogs.

ABSTRACT:

Background

Fibrocartilaginous embolic myelopathy (FCE) is a well-documented condition in dogs although rarely reported in chondrodystrophic breeds. Genetic associations have not been defined.

Objectives

Define the association of the chondrodystrophy-associated FGF4L2 retrogene with histopathologically confirmed cases of FCE.

Animals

Ninety-eight dogs with a histopathologic diagnosis of FCE.

Methods

Retrospective multicenter study. Dogs were genotyped for the FGF4L2 and FGF4L1 retrogenes using DNA extracted from formalin-fixed, paraffin-embedded tissue. Associations between breed, FCE and retrogene status were investigated with reference to a hospital population and known breed and general population allele frequencies.

Results

FGF4L2 genotype was defined

SUBMITTER: Embersics C 

PROVIDER: S-EPMC10800192 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature