MicroRNA-126 in dogs with immune complex-mediated glomerulonephritis.

ABSTRACT:

Background

Most proteinuric dogs with naturally occurring chronic kidney disease have amyloidosis (AMYL), glomerulosclerosis (GS), or immune complex-mediated glomerulonephritis (ICGN), each with different treatment and prognosis. A noninvasive and disease-specific biomarker is lacking.

Hypothesis

We hypothesized that the expression pattern of biofluid microRNA (miRNAs and miRs) would correlate with disease progression and categorization.

Animals

Archived serum and urine samples from 18 dogs with glomerular disease and 6 clinically healthy dogs; archived urine samples from 49 dogs with glomerular disease and 13 clinically healthy dogs.

Methods

Retrospective study. Archived biofluid samples from adult dogs with biopsy-confirmed glomerular disease submitted to the

SUBMITTER: Cherry AD 

PROVIDER: S-EPMC10800198 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature