Severe asthma in horses is associated with increased airway innervation.

ABSTRACT:

Background

Altered innervation structure and function contribute to airway hyperresponsiveness in human asthma, yet the role of innervation in airflow limitation in asthma in horses remains unknown.

Hypothesis

To characterize peribronchial innervation in horses with asthma. We hypothesized that airway innervation increases in horses with asthma compared with controls.

Animals

Formalin-fixed lung samples from 8 horses with severe asthma and 8 healthy horses from the Equine Respiratory Tissue Biobank. Ante-mortem lung function was recorded.

Methods

Blinded case-control study. Immunohistochemistry was performed using rabbit anti-s100 antibody as a neuronal marker for myelinating and non-myelinating Schwann cells. The number and cumulative area of nerves in the per

SUBMITTER: Leduc L 

PROVIDER: S-EPMC10800206 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature