Polioencephalopathy in Eurasier dogs.

ABSTRACT:

Background

Polioencephalopathies secondary to inborn errors of metabolism have been described in dogs, but few genetically characterized.

Objectives

Clinically and genetically characterize polioencephalopathy in a family of Eurasier dogs.

Animals

Three Eurasier dogs (littermates) presented with early onset movement disorders (9 weeks in 2, 4-6 months in 1). Progressive gait abnormalities were detected in 2 of the dogs, persistent divergent strabismus in 1, whereas consciousness and behavior remained intact in all dogs. One dog was euthanized at 25 months.

Methods

Video footage was assessed in all dogs, and Dogs 1 and 2 had examinations and investigations performed. Whole genome sequencing of Dog 1 and further genetic analyses in the family were performed. A coh

SUBMITTER: Rawson F 

PROVIDER: S-EPMC10800227 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature