Efficacy of a mitral regurgitation severity index to predict long-term outcome in dogs with myxomatous mitral valve disease.

ABSTRACT:

Background

Predicting progression of myxomatous mitral valve disease (MMVD) in dogs can be challenging.

Hypothesis/objectives

The mitral regurgitation severity index (MRSI) will predict time to congestive heart failure (CHF) and all-cause death in dogs with MMVD.

Animals

Eight hundred sixty-nine client-owned dogs.

Methods

Retrospective study pooling data from 4 previous samples including dogs with MMVD stage B2 or C. MRSI was calculated as: (heart rate [HR]/120) × left atrium-to-aorta ratio (LA:Ao) × (age in years/10) × 100. Alternative MRSI formulas substituting radiographic measures of left atrial size were also calculated. Cox proportional hazard modeling and time-dependent receiver-operator characteristic curves quantified prognostic performance.

Results

SUBMITTER: Vereb M 

PROVIDER: S-EPMC10800232 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature