Early intranasal medication administration in out-of-hospital cardiac arrest: Two randomized simulation trials.

ABSTRACT:

Objective

Intranasal medications have been proposed as adjuncts to out-of-hospital cardiac arrest (OHCA) care. We sought to quantify the effects of intranasal medication administration (INMA) in OHCA workflows.

Methods

We conducted separate randomized OHCA simulation trials with lay rescuers (LRs) and first responders (FRs). Participants were randomized to groups performing hands-only cardiopulmonary resuscitation (CPR)/automated external defibrillator with or without INMA during the second analysis phase. Time to compression following the second shock (CPR2) was the primary outcome and compression quality (chest compression rate (CCR) and fraction (CCF)) was the secondary outcome. We fit linear regression models adjusted for CPR training in the LR group and service years in

SUBMITTER: Dowker SR 

PROVIDER: S-EPMC10800291 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature