Human amnion epithelial cell therapy reduces hypertension-induced vascular stiffening and cognitive impairment.

ABSTRACT: Vascular inflammation and fibrosis are hallmarks of hypertension and contribute to the development of cardiovascular disease and cognitive impairment. However, current anti-hypertensive drugs do not treat the underlying tissue damage, such as inflammation-associated fibrosis. Human amnion epithelial cells have several properties amenable for treating vascular pathology. This study tested the effect of amnion epithelial cells on vascular pathology and cognitive impairment during hypertension. Male C57Bl6 mice (8-12 weeks) were administered vehicle (saline; n = 58) or angiotensin II (0.7 mg/kg/d, n = 56) subcutaneously for 14 d. After surgery, a subset of mice were injected with 10⁶ amnion epithelial cells intravenously. Angiotensin II infusion increased systolic blood pressure, a

SUBMITTER: Dinh QN 

PROVIDER: S-EPMC10800338 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature