Association between intracranial and extracranial atherosclerosis and white matter hyperintensities: a systematic review and meta-analysis.

ABSTRACT:

Background

White matter hyperintensities (WMHs) are key neuroimaging markers of cerebral small vessel diseases. This study aimed to investigate whether intracranial and extracranial atherosclerotic stenosis is associated with WMHs.

Methods

Following a previously registered protocol (PROSPERO protocol: CRD42023407465), PubMed, Web of Science, and Embase were systematically searched for relevant literature published until March 2023. Cross-sectional studies examining the association between intracranial and extracranial atherosclerotic stenosis and WMHs were included. Random effects models were used to calculate the pooled estimates.

Results

Twenty-one eligible studies, including 10,841 participants, were identified. Intracranial and extracranial atherosclerotic stenosi

SUBMITTER: Zhang W 

PROVIDER: S-EPMC10800362 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature