The immunomodulatory effects of mesenchymal stem cell-derived extracellular vesicles in Alzheimer's disease.

ABSTRACT: Neuroinflammation has been identified as another significant pathogenic factor in Alzheimer's disease following Aβ amyloid deposition and tau protein hyperphosphorylation, activated in the central nervous system by glial cells in response to injury-related and pathogen-related molecular patterns. Moderate glial cell activity can be neuroprotective; however, excessive glial cell activation advances the pathology of Alzheimer's disease and is accompanied by structural changes in the brain interface, with peripheral immune cells entering the brain through the blood-brain barrier, creating a vicious circle. The immunomodulatory properties of mesenchymal stem cells (MSCs) are primarily conveyed through extracellular vesicles (EVs). MSC-EVs participate in chronic inflammatory and immune processe

SUBMITTER: Ye Y 

PROVIDER: S-EPMC10800421 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature