The relationship between education attainment and gout, and the mediating role of modifiable risk factors: a Mendelian randomization study.

ABSTRACT:

Objective

To investigate the causal relationship between educational attainment (EA) and gout, as well as the potential mediating effects of individual physical status (IPS) such as body mass index (BMI) and systolic blood pressure (SBP) and lifestyle habits (LH) including alcohol intake frequency (drinking), current tobacco smoking (smoking), and time spent watching television (TV).

Methods

Utilizing two-sample Mendelian randomization (MR), we analyzed the causal effects of EA on gout risk, and of IPS (BMI and SBP) and LH (smoking, drinking, and TV time) on gout risk. Multivariable MR (MVMR) was employed to explore and quantify the mediating effects of IPS and LH on the causal relationship between EA and gout risk.

Results

An elevation of educational attainment by on

SUBMITTER: Huang X 

PROVIDER: S-EPMC10800502 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature