Therapeutic efficacy of sulforaphane in autism spectrum disorders and its association with gut microbiota: animal model and human longitudinal studies.

ABSTRACT:

Introduction

Sulforaphane (SFN) has been found to alleviate complications linked with several diseases by regulating gut microbiota (GM), while the effect of GM on SFN for autism spectrum disorders (ASD) has not been studied. Therefore, this study aimed to investigate the relationship between the effects of SFN on childhood ASD and GM through animal model and human studies.

Methods

We evaluated the therapeutic effects of SFN on maternal immune activation (MIA) induced ASD-like rat model and pediatric autism patients using three-chamber social test and OSU Autism Rating Scale-DSM-IV (OARS-4), respectively, with parallel GM analysis using 16SrRNA sequencing.

Results

SFN significantly improved the sniffing times of ASD-like rats in the three-chamber test. For human parti

SUBMITTER: Yang J 

PROVIDER: S-EPMC10800504 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature