Causal association between gut microbiota and fibromyalgia: a Mendelian randomization study.

ABSTRACT:

Background

Fibromyalgia (FM) is a syndrome characterized by chronic and widespread musculoskeletal pain. A number of studies have implied a potential association between gut microbiota and FM. However, the casual association between gut microbiota and FM remains unknown.

Method

Mendelian randomization (MR) study was conducted using the summary statistics of genetic variants from the genome-wide association study (GWAS). Inverse variance weighted (IVW), combined with MR-Egger and weighted median were used to investigate the causal association between 119 gut microbiota genera and FM. Sensitivity analyses were performed on the MR results, including heterogeneity test, leave-one-out test and pleiotropy test.

Results

A total of 1,295 single nucleotide polymorphism (SNPs)

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10800605 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature