Micropopulation mapping of the mouse parafascicular nucleus connections reveals diverse input-output motifs.

ABSTRACT:

Introduction

In primates, including humans, the centromedian/parafascicular (CM-Pf) complex is a key thalamic node of the basal ganglia system. Deep brain stimulation in CM-Pf has been applied for the treatment of motor disorders such as Parkinson's disease or Tourette syndrome. Rodents have become widely used models for the study of the cellular and genetic mechanisms of these and other motor disorders. However, the equivalence between the primate CM-Pf and the nucleus regarded as analogous in rodents (Parafascicular, Pf) remains unclear.

Methods

Here, we analyzed the neurochemical architecture and carried out a brain-wide mapping of the input-output motifs in the mouse Pf at micropopulation level using anterograde and retrograde labeling methods. Specifically, we mapped an

SUBMITTER: Gonzalo-Martin E 

PROVIDER: S-EPMC10800635 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature