A zinc metabolism-related gene signature for predicting prognosis and characteristics of breast cancer.

ABSTRACT:

Background

Breast cancer is one of the most serious and prevalent malignancies. Zinc is commonly known to play a crucial role in the development and progression of breast cancer; however, the detailed mechanisms underlying this role are not well understood. This study aimed to develop a zinc metabolism-related gene (ZMRG) signature based on a multi-database study to predict patient prognosis and investigate the relationship between drug therapy response and immune enrichment.

Methods

Data for breast cancer samples from The Cancer Genome Atlas and Gene Expression Omnibus databases were screened for zinc metabolism-related genes using the Molecular Signature Database. Cox and Least Absolute Shrinkage and Selection Operator regressions were performed to construct a ZMRG signatu

SUBMITTER: Hong J 

PROVIDER: S-EPMC10800782 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature