Non-alcoholic fatty liver disease causally affects the brain cortical structure: a Mendelian randomization study.

ABSTRACT:

Background

Reduced brain volume, impaired cognition, and possibly a range of psychoneurological disorders have been reported in patients with non-alcoholic fatty liver disease (NAFLD); however, no underlying cause has been specified. Here, Mendelian randomization (MR) was employed to determine the causative NAFLD effects on cortical structure.

Methods

We used pooled-level data from FinnGen's published genome-wide association study (GWAS) of NAFLD (1908 cases and 340,591 healthy controls), as well as published GWAS with NAFLD activity score (NAS) and fibrosis stage-associated SNPs as genetic tools, in addition to the Enigma Consortium data from 51,665 patients, were used to assess genetic susceptibility in relation to changes with cortical thickness (TH) and surface area (SA)

SUBMITTER: Lin YK 

PROVIDER: S-EPMC10800802 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature