Chronic blue light-emitting diode exposure harvests gut dysbiosis related to cholesterol dysregulation.

ABSTRACT: Night shift workers have been associated with circadian dysregulation and metabolic disorders, which are tightly coevolved with gut microbiota. The chronic impacts of light-emitting diode (LED) lighting at night on gut microbiota and serum lipids were investigated. Male C57BL/6 mice were exposed to blue or white LED lighting at Zeitgeber time 13.5-14 (ZT; ZT0 is the onset of "lights on" and ZT12 is the "lights off" onset under 12-hour light, 12-hour dark schedule). After 33 weeks, only the high irradiance (7.2 J/cm²) of blue LED light reduced the alpha diversity of gut microbiota. The high irradiance of white LED light and the low irradiance (3.6 J/cm²) of both lights did not change microbial alpha diversity. However, the low irradiance, but not the high one, of both

SUBMITTER: Huang CH 

PROVIDER: S-EPMC10800827 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature