Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect.

ABSTRACT: The rapid relief of depressive symptoms is a major medical requirement for effective treatments for major depressive disorder (MDD). A decrease in neuroactive steroids contributes to the pathophysiological mechanisms associated with the neurological symptoms of MDD. Zuranolone (SAGE-217), a neuroactive steroid that acts as a positive allosteric modulator of synaptic and extrasynaptic δ-subunit-containing GABA_A receptors, has shown rapid-onset, clinically effective antidepressant action in patients with MDD or postpartum depression (PPD). Benzodiazepines, on the other hand, act as positive allosteric modulators of synaptic GABA_A receptors but are not approved for the treatment of patients with MDD. It remains unclear how differences in molecular mechanisms contribute t

SUBMITTER: Takasu K 

PROVIDER: S-EPMC10800935 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature