Melatonin as an anti-stress signal: effects on an acute stress model and direct actions on interrenal tissue in goldfish.

ABSTRACT:

Background

Melatonin is a key hormone in regulation of circadian rhythms, and involved in many rhythmic functions, such as feeding and locomotor activity. Melatonin reportedly counteracts stress responses in many vertebrates, including fish. However, targets for this action of melatonin and underlying mechanisms remain unknown.

Results

This study reports potential anti-stress properties of melatonin in goldfish (Carassius auratus), with a focus on its effect on plasma cortisol, food intake, and locomotor activity, all of them involved in the responses to stress exposure. Indeed, acute injection of melatonin counteracted stress-induced hypercortisolinemia and reduced food intake. The reduced locomotor activity following melatonin treatment suggests a possible sedative

SUBMITTER: Azpeleta C 

PROVIDER: S-EPMC10800973 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature