Age-related alterations in the behavioral response to a novel environment in the African turquoise killifish (Nothobranchius furzeri).

ABSTRACT: The African turquoise killifish (Nothobranchius furzeri) has emerged as a popular model organism for neuroscience research in the last decade. One of the reasons for its popularity is its short lifespan for a vertebrate organism. However, little research has been carried out using killifish in behavioral tests, especially looking at changes in their behavior upon aging. Therefore, we used the open field and the novel tank diving test to unravel killifish locomotion, exploration-related behavior, and behavioral changes over their adult lifespan. The characterization of this behavioral baseline is important for future experiments involving pharmacology to improve the aging phenotype. In this study, two cohorts of fish were used, one cohort was tested in the open field test and one coh

SUBMITTER: Marien V 

PROVIDER: S-EPMC10800983 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature