Investigating chromosomal instability in long-term survivors with glioblastoma and grade 4 astrocytoma.

ABSTRACT:

Background

Only a small group of patients with glioblastoma multiforme (GBM) survives more than 36 months, so-called long-term survivors. Recent studies have shown that chromosomal instability (CIN) plays a prognostic and predictive role among different cancer types. Here, we compared histological (chromosome missegregation) and bioinformatic metrics (CIN signatures) of CIN in tumors of GBM typical survivors (≤36 months overall survival), GBM long-term survivors and isocitrate dehydrogenase (IDH)-mutant grade 4 astrocytomas.

Methods

Tumor sections of all gliomas were examined for anaphases and chromosome missegregation. Further CIN signature activity analysis in the The Cancer Genome Atlas (TCGA)-GBM cohort was performed.

Results

Our data show that chromosome missegre

SUBMITTER: Spoor JKH 

PROVIDER: S-EPMC10800987 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature