MXSGD alleviates CsA-induced hypoimmunity lung injury by regulating microflora metabolism.

ABSTRACT:

Context

Ma Xing Shi Gan Decoction (MXSGD) is a traditional remedy for treating lung injuries that was developed by the Typhoid and Fever School of Pharmaceutical Biology. It has antitussive and expectorant effects, anti-inflammatory, antiviral, regulates the body's immunity, etc.

Aim

The aim of this study is to investigate whether MXSGD can ameliorate cyclosporine A (CsA)-induced hypoimmunity lung injury by regulating microflora metabolism. Methods: Establishment of a model for CsA-induced hypoimmunity lung injury. Using 16S rRNA high-throughput sequencing and LC-MS, the effects of MXSGD on gut flora and lung tissue microecology of mice with CsA-induced hypoimmunity were investigated.

Results

MXSGD was able to preserve lung tissue morphology and structure, reduce seru

SUBMITTER: Ye C 

PROVIDER: S-EPMC10801022 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature