Metabolic activity of visceral adipose tissue is associated with age-related macular degeneration: a pilot ¹⁸F-FDG PET/CT study.

ABSTRACT:

Background

Obesity is known to increase the risk and severity of age-related macular degeneration (AMD). Increased inflamed metabolic activity of visceral adipose tissue (VAT) is considered as a crucial underlying mechanism for the harmful effects of obesity. In this study, we aimed to investigate the inflamed metabolic activity of VAT with ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and their association with AMD.

Materials and methods

A total of 57 elderly participants (aged ≥ 50 years) who underwent ¹⁸F-FDG PET/CT for health screening and subsequent fundoscopic exam for complaint of recently impaired vision were enrolled. The metabolic activity of VAT was measured from the maximum standardized uptake value (

SUBMITTER: Choi KE 

PROVIDER: S-EPMC10801050 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature