In vitro antibacterial activity of antiretroviral drugs on key commensal bacteria from the human microbiota.

ABSTRACT:

Introduction

Antiretroviral therapy has improved life expectancy in HIV-infected patients. However, people living with HIV under antiretroviral therapy are at higher risks of developing chronic complications and acquiring multidrug resistant bacteria than healthy population. These factors have been associated with shifts in gut microbiome composition and immune activation. It is unclear how antiretroviral drugs affect gut microbiota composition, but it has been observed that antiretroviral treatment is not able to fully restore gut health after HIV infection. Additionally, some antiretroviral drugs have shown antibacterial activity suggesting that these drugs could have a direct impact on the human microbiome composition.

Methods

We determined the in vitro antibacteri

SUBMITTER: Rubio-Garcia E 

PROVIDER: S-EPMC10801051 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature