Circulating levels of inflammatory mediators in pregnant people living with HIV according to antiretroviral therapy regimen.

ABSTRACT:

Introduction

The use of antiretroviral therapy (ART) during pregnancy, particularly protease-inhibitor-based regimens (PI), has been linked to adverse outcomes including preterm delivery. As this outcome may be related to systemic inflammation, we sought to characterize inflammatory profiles of pregnant people living with HIV (PLWH) by comparing their levels of inflammatory mediators at two timepoints during pregnancy according to ART regimen, and to HIV-negative controls.

Methods

Second and third trimester samples from 144 pregnant PLWH treated with ART and 24 HIV-uninfected controls were retrieved from the CARMA-PREG cohort. Peripheral plasma levels of 12 inflammatory mediators previously linked to HIV infection and/or poor pregnancy outcomes were quantified by multiplex a

SUBMITTER: Hindle S 

PROVIDER: S-EPMC10801078 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature