Causal association between obesity and hypothyroidism: a two-sample bidirectional Mendelian randomization study.

ABSTRACT:

Introduction

Previous observational studies have reported a positive correlation between obesity and susceptibility to hypothyroidism; however, there is limited evidence from alternative methodologies to establish a causal link.

Methods

We investigated the causal relationship between obesity and hypothyroidism using a two-sample bidirectional Mendelian randomization (MR) analysis. Single-nucleotide polymorphisms (SNPs) associated with obesity-related traits were extracted from a published genome-wide association study (GWAS) of European individuals. Summarized diagnostic data of hypothyroidism were obtained from the UK Biobank. Primary analyses were conducted using the inverse variance-weighted (IVW) method with a random-effects model as well as three complementary approache

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC10801094 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature