Association between tamoxifen and incidence of osteoporosis in Korean patients with ductal carcinoma in situ.

ABSTRACT:

Introduction

The partial estrogen-agonist action of tamoxifen on bone receptors has beneficial effects on bone mineral density. However, in premenopausal women, the use of tamoxifen causes systemic estrogen depletion, which has detrimental effects on bone health. We aim to investigate the association between tamoxifen and osteoporosis in the real world using data from a longitudinal nationwide cohort of Korean patients.

Methods

Data were collected from the National Health Insurance claims database in South Korea. Osteoporosis was defined by diagnostic codes accompanying prescription data for osteoporosis. The cumulative incidence was analyzed by Kaplan-Meier survival curves and the risk factors were analyzed using a multivariable Cox proportional hazard regression model.

SUBMITTER: Kim D 

PROVIDER: S-EPMC10801186 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature