Efficacy and safety of adjuvant radiation therapy in localized adrenocortical carcinoma.

ABSTRACT:

Context

Adrenocortical carcinoma (ACC) is rare and have high rates of recurrence and mortality. The role of adjuvant radiation therapy (RT) in localized ACC was controversial.

Methods

We conducted a retrospective study in our center between 2015 and 2021 to evaluate the efficacy and safety of adjuvant RT in localized ACC. Overall survival (OS) and disease-free survival (DFS) were estimated using the Kaplan-Meier method. Cox proportional hazards regression models were used to estimate the independent risk factors. Adverse events associated with RT were documented according to the toxicity criteria of the radiation therapy oncology group (RTOG) and the common terminology criteria for adverse events (CTCAE v5.0).

Results

Of 105 patients with localized ACC, 46 (43.8%) rec

SUBMITTER: Wu L 

PROVIDER: S-EPMC10801189 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature