The effect of daily oral PrEP use during pregnancy on bone mineral density among adolescent girls and young women in Uganda.

ABSTRACT:

Introduction

Oral pre-exposure prophylaxis (PrEP) is recommended during pregnancy for at-risk cisgender women. Pregnancy is known to impede bone growth and tenofovir-based PrEP may also yield detrimental changes to bone health. Thus, we evaluated the effect of PrEP use during pregnancy on bone mineral density (BMD).

Methods

We used data from a cohort of women who were sexually active, HIV-negative, ages 16-25 years, initiating DMPA or choosing condoms for contraception and enrolled in the Kampala Women's Bone Study. Women were followed quarterly with rapid testing for HIV and pregnancy, PrEP dispensation, and adherence counseling. Those who became pregnant were counseled on PrEP use during pregnancy per national guidelines. BMD of the neck of the hip, total hip, and lumbar s

SUBMITTER: Zewdie K 

PROVIDER: S-EPMC10801233 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature